Overweight people who frequently take
aspirin at night lowers their risk of getting cancer, according to a new
research.
British researchers assessed the
effects of aspirin during a 10-year study of 937 participants with Lynch
syndrome – a form of inherited cancer linked with a genetic predisposition to various
types of cancers. To put it simply, people with Lynch syndrome are at a higher
risk of getting afflicted with certain forms of cancer, especially colon and
womb cancer.
Scientists from 16 countries were involved in the research.
They discovered that overweight people were twice the risk of developing colon
cancer. But, the risk could be reversed if these patients were administered a
regular dose of aspirin.
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The study was published in the Journal of Clinical Oncology, and was
funded by the Cancer Research UK, UK Medical Research Council, Bayer Pharma and
the European Union.
Study author Sir
John Burn of Newcastle University in the UK said, although this is
important for Lynch Syndrome patients, it affects all of us.
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Our body’s inflammatory response is increased by obesity.
That inflammation may be suppressed by aspirin and this provides us with new ways
of research into the causes of various cancers, Sir Burn explains.
The study showed that the benefits of aspirin seemed to
occur before the earliest stages of developing tumor. They believe that this is
due to the fact that aspirin may affect cells that are predisposed to becoming
cancerous over time.
Prof. Burn says we may be observing a mechanism in humans
where genetically warped stem cells are undergoing programmed cell death by the
encouragement of aspirin. This would, he adds, impact cancer.
The scientists examined the progress of participants with
Lynch syndrome who were randomly assigned to either take two aspirins (600 mg)
a day for 2 years or a placebo.
When the participants were followed up 10 years later, it
showed that a total of 55 had developed bowel cancer. They found that overweight
people were more likely, in fact 2.75 times more likely to develop cancer than
those who were of normal weight.
This study shows that daily aspirin intake of 600 mg
eliminated the majority of the heightened risk linked with higher Body Mass
Index (BMI), explained Prof. Tim Bishop, a lead author from the University of
Leeds.
The researchers however cautioned that before anyone decides
on daily aspirin intake, they should ask a healthcare professional first; Aspirin
is known to cause ulcers and other stomach complications.
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